Effect of Structural Modifications to Glyoxal-bis(thiosemicarbazonato)copper(II) Complexes on Cellular Copper Uptake, Copper-Mediated ATP7A Trafficking, and P-Glycoprotein Mediated Efflux
Author:
Affiliation:
1. Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria 3084, Australia
2. Centre for PET, Department of Molecular Imaging & Therapy, Austin Health, 145 Studley Road, Heidelberg, Victoria 3084, Australia
Funder
National Health and Medical Research Council
Australian Research Council
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b01158
Reference58 articles.
1. Redox-active metal complexes for imaging hypoxic tissues: structure–activity relationships in copper(ii) bis(thiosemicarbazone) complexes
2. Copper bis(thiosemicarbazone) complexes as hypoxia imaging agents: structure-activity relationships
3. Transfer of Copper between Bis(thiosemicarbazone) Ligands and Intracellular Copper-Binding Proteins. Insights into Mechanisms of Copper Uptake and Hypoxia Selectivity
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