Discovery of LY3104607: A Potent and Selective G Protein-Coupled Receptor 40 (GPR40) Agonist with Optimized Pharmacokinetic Properties to Support Once Daily Oral Treatment in Patients with Type 2 Diabetes Mellitus-Reference-Cited by-同舟云学术

Discovery of LY3104607: A Potent and Selective G Protein-Coupled Receptor 40 (GPR40) Agonist with Optimized Pharmacokinetic Properties to Support Once Daily Oral Treatment in Patients with Type 2 Diabetes Mellitus

Published:2018-01-05 Issue:3 Volume:61 Page:934-945
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Hamdouchi Chafiq¹^ORCID,Maiti Pranab²,Warshawsky Alan M.¹,DeBaillie Amy C.¹,Otto Keith A.¹,Wilbur Kelly L.¹,Kahl Steven D.¹,Patel Lewis Anjana¹,Cardona Guemalli R.¹,Zink Richard W.¹,Chen Keyue¹,CR Siddaramaiah²,Lineswala Jayana P.¹,Neathery Grace L.¹,Bouaichi Cecilia¹,Diseroad Benjamin A.¹,Campbell Alison N.¹,Sweetana Stephanie A.¹,Adams Lisa A.¹,Cabrera Over¹,Ma Xiaosu¹,Yumibe Nathan P.¹,Montrose-Rafizadeh Chahrzad¹,Chen Yanyun¹,Miller Anne Reifel¹

Affiliation:

1. Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, DC: 0540, Indianapolis, Indiana 46285, United States

2. Jubilant Biosys Research Center, Bangalore, India

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b01411

Reference29 articles.

1. World Health Organization. Global Report on Diabetes.http://apps.who.int/iris/bitstream/10665/204871/1/9789241565257_eng.pdf(accessed May 26, 2016) .

2. Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules

3. Oleic acid interacts with GPR40 to induce Ca2+signaling in rat islet β-cells: mediation by PLC and L-type Ca2+channel and link to insulin release

4. Overexpression of GPR40 in Pancreatic β-Cells Augments Glucose-Stimulated Insulin Secretion and Improves Glucose Tolerance in Normal and Diabetic Mice

5. Free fatty acids increase cytosolic free calcium and stimulate insulin secretion from β-cells through activation of GPR40

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