Addressing Structural Flexibility at the A-Ring on Salvinorin A: Discovery of a Potent Kappa-Opioid Agonist with Enhanced Metabolic Stability-Reference-Cited by-同舟云学术

Addressing Structural Flexibility at the A-Ring on Salvinorin A: Discovery of a Potent Kappa-Opioid Agonist with Enhanced Metabolic Stability

Published:2017-04-19 Issue:9 Volume:60 Page:3866-3878
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Sherwood Alexander M.¹,Crowley Rachel Saylor¹,Paton Kelly F.²,Biggerstaff Andrew²,Neuenswander Benjamin¹,Day Victor W.³,Kivell Bronwyn M.²,Prisinzano Thomas E.¹^ORCID

Affiliation:

1. Department of Medicinal Chemistry, School of Pharmacy, The University of Kansas, Lawrence, Kansas 66045, United States

2. School of Biological Sciences, Centre for Biodiscovery, Victoria University of Wellington, Wellington 6012, New Zealand

3. Department of Chemistry, The University of Kansas, Lawrence, Kansas 66045, United States

Funder

Health Research Council of New Zealand

American Foundation for Pharmaceutical Education

National Institute on Drug Abuse

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b00148

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