Synthesis and Pharmacological Evaluation of Heterocyclic Carboxamides: Positive Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor with Weak Agonist Activity and Diverse Modulatory Profiles-Reference-Cited by-同舟云学术

Synthesis and Pharmacological Evaluation of Heterocyclic Carboxamides: Positive Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor with Weak Agonist Activity and Diverse Modulatory Profiles

Published:2018-03-15 Issue:7 Volume:61 Page:2875-2894
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Dallagnol Juliana C. C.¹²,Khajehali Elham³,van der Westhuizen Emma T.³,Jörg Manuela¹,Valant Celine³,Gonçalves Alan G.²,Capuano Ben¹,Christopoulos Arthur³,Scammells Peter J.¹^ORCID

Affiliation:

1. Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia

2. Department of Pharmacy, Federal University of Parana, Avenida Prefeito Lothario Meissner 632, Jardim Botanico, Curitiba, Parana, Brazil

3. Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences & Department of Pharmacology, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia

Funder

National Health and Medical Research Council

Australian Research Council

Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b01812

Reference38 articles.

1. Deletion of M1 Muscarinic Acetylcholine Receptors Increases Amyloid Pathology In Vitro and In Vivo