Pyrazolopyrimidines as Potent Stimulators for Transient Receptor Potential Canonical 3/6/7 Channels

Author:

Qu Chunrong1,Ding Mingmin1,Zhu Yingmin2,Lu Yungang2,Du Juan3,Miller Melissa4,Tian Jinbin2,Zhu Jinmei1,Xu Jian56,Wen Meng1,Er-Bu AGA7,Wang Jule7,Xiao Yuling1,Wu Meng4,McManus Owen B.4,Li Min4,Wu Jilin68,Luo Huai-Rong9,Cao Zhengyu5,Shen Bing3,Wang Hongbo10,Zhu Michael X.26,Hong Xuechuan17ORCID

Affiliation:

1. State Key Laboratory of Virology, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE) and Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, Wuhan University School of Pharmaceutical Sciences, Wuhan, Hubei Province 430071, China

2. Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas 77030, United States

3. School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui Province 230032, China

4. Department of Neuroscience, High Throughput Biology Center and Johns Hopkins Ion Channel Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States

5. State Key Laboratory of Natural Medicines, Jiangsu Provincial Key laboratory for TCM Evaluation and Translational Development, China Pharmaceutical University, Nanjing, Jiangsu Province 211198, China

6. The International Scientist Working Station of Neuropharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China

7. Medical College, Tibet University, Lasa, Tibet 850000, China

8. University of Chinese Academy of Sciences, Beijing, 100049, China

9. Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan Province 650201, China

10. School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Yantai University, Yantai, Shangdong Province 264005, China

Funder

National Institute of Neurological Disorders and Stroke

Ministry of Education of the People's Republic of China

Ministry of Science and Technology of the People's Republic of China

Natural Science Foundation of Jiangsu Province

Natural Science Foundation of Hubei Province

National Institute of Mental Health

National Natural Science Foundation of China

Beijing Nova Program

Scientific and Technologic Council of Suzhou

Wuhan Municipal Bureau of Science and Technology

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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