Neuroactive Steroids. 2. 3α-Hydroxy-3β-methyl-21-(4-cyano-1H-pyrazol-1′-yl)-19-nor-5β-pregnan-20-one (SAGE-217): A Clinical Next Generation Neuroactive Steroid Positive Allosteric Modulator of the (γ-Aminobutyric Acid)A Receptor-Reference-Cited by-同舟云学术

Neuroactive Steroids. 2. 3α-Hydroxy-3β-methyl-21-(4-cyano-1H-pyrazol-1′-yl)-19-nor-5β-pregnan-20-one (SAGE-217): A Clinical Next Generation Neuroactive Steroid Positive Allosteric Modulator of the (γ-Aminobutyric Acid)A Receptor

Published:2017-08-17 Issue:18 Volume:60 Page:7810-7819
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Martinez Botella Gabriel¹,Salituro Francesco G.¹^ORCID,Harrison Boyd L.¹,Beresis Richard T.²,Bai Zhu³,Blanco Maria-Jesus¹^ORCID,Belfort Gabriel M.¹,Dai Jing¹,Loya Carlos M.¹,Ackley Michael A.¹,Althaus Alison L.¹,Grossman Scott J.¹,Hoffmann Ethan¹,Doherty James J.¹,Robichaud Albert J.¹

Affiliation:

1. Sage Therapeutics, Inc. 215 First Street, Cambridge, Massachusetts 02142, United States

2. Shanghai Chempartner, 998 Halei Road, Shanghai 201203, China

3. WuXi AppTec, 288 Fute Zhong Road, Shanghai 200131, China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b00846

Reference32 articles.

1. Natural and Synthetic Neuroactive Steroid Modulators of GABAA and NMDA Receptors