In Silico Identification of a Novel Hinge-Binding Scaffold for Kinase Inhibitor Discovery-Reference-Cited by-同舟云学术

In Silico Identification of a Novel Hinge-Binding Scaffold for Kinase Inhibitor Discovery

Published:2017-10-16 Issue:20 Volume:60 Page:8552-8564
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wang Yanli¹,Sun Yuze¹²,Cao Ran¹,Liu Dan¹,Xie Yuting¹,Li Li¹,Qi Xiangbing¹^ORCID,Huang Niu¹^ORCID

Affiliation:

1. National Institute of Biological Sciences, Beijing, No. 7 Science Park Road, Zhongguancun Life Science Park, Beijing 102206, China

2. Peking University-Tsinghua University-National Institute of Biological Sciences Joint Graduate Program, School of Life Sciences, Tsinghua University, Beijing 100084, China

Funder

Ministry of Science and Technology of the People's Republic of China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b01075

Reference68 articles.

1. Unexpected Off-Targets and Paradoxical Pathway Activation by Kinase Inhibitors

2. Kinase targets in CNS drug discovery

3. High-throughput kinase profiling as a platform for drug discovery

4. Kinase-targeted libraries: The design and synthesis of novel, potent, and selective kinase inhibitors

5. Knowledge Based Prediction of Ligand Binding Modes and Rational Inhibitor Design for Kinase Drug Discovery

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