N6-Substituted 5′-N-Methylcarbamoyl-4′-selenoadenosines as Potent and Selective A3 Adenosine Receptor Agonists with Unusual Sugar Puckering and Nucleobase Orientation

Author:

Yu Jinha1,Zhao Long Xuan12,Park Jongmi3,Lee Hyuk Woo1,Sahu Pramod K.1,Cui Minghua3,Moss Steven M.4,Hammes Eva4,Warnick Eugene4,Gao Zhan-Guo4,Noh Minsoo1,Choi Sun3ORCID,Ahn Hee-Chul5,Choi Jungwon6,Jacobson Kenneth A.4ORCID,Jeong Lak Shin1ORCID

Affiliation:

1. Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151-742, Korea

2. College of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian 116-029, China

3. College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Korea

4. Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes, and Digestive and Kidney Disease, National Institutes of Health, Bethesda, Maryland 20892, United States

5. College of Pharmacy, Dongguk University, Goyang, Gyeonggi-do 410-820, Korea

6. Department of Chemistry, The University of Suwon, Hwaseong, Gyeonggi-do 445-743, Korea

Funder

National Institute of Diabetes and Digestive and Kidney Diseases

National Research Foundation of Korea

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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