Discovery of an Orally Bioavailable Benzimidazole Diacylglycerol Acyltransferase 1 (DGAT1) Inhibitor That Suppresses Body Weight Gain in Diet-Induced Obese Dogs and Postprandial Triglycerides in Humans-Reference-Cited by-同舟云学术

Discovery of an Orally Bioavailable Benzimidazole Diacylglycerol Acyltransferase 1 (DGAT1) Inhibitor That Suppresses Body Weight Gain in Diet-Induced Obese Dogs and Postprandial Triglycerides in Humans

Published:2017-05-24 Issue:11 Volume:60 Page:4657-4664
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Nakajima Katsumasa¹^ORCID,Chatelain Ricardo¹,Clairmont Kevin B.¹,Commerford Renee¹,Coppola Gary M.¹,Daniels Thomas¹,Forster Cornelia J.¹,Gilmore Thomas A.¹,Gong Yongjin¹,Jain Monish¹,Kanter Aaron¹,Kwak Youngshin¹,Li Jingzhou¹,Meyers Charles D.¹,Neubert Alan D.¹,Szklennik Paul¹,Tedesco Vivienne¹,Thompson James¹,Truong David¹,Yang Qing¹,Hubbard Brian K.¹,Serrano-Wu Michael H.¹

Affiliation:

1. Global Discovery Chemistry, ‡Cardiovascular and Metabolism, ∥PK Sciences, and §Translational Medicine, Novartis Institutes for Biomedical Research, 100 Technology Square, Cambridge, Massachusetts 02139, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b00173

Reference21 articles.

1. Triglycerides and Cardiovascular Disease

2. Acute Pancreatitis in a Cohort of 129 Patients Referred for Severe Hypertriglyceridemia

3. Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis

4. Cloning of DGAT2, a Second Mammalian Diacylglycerol Acyltransferase, and Related Family Members

5. Lipopenia and Skin Barrier Abnormalities in DGAT2-deficient Mice

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