Tumor Targeting with Novel Pyridyl 6-Substituted Pyrrolo[2,3-d]Pyrimidine Antifolates via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of De Novo Purine Nucleotide Biosynthesis-Reference-Cited by-同舟云学术

Tumor Targeting with Novel Pyridyl 6-Substituted Pyrrolo[2,3-d]Pyrimidine Antifolates via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of De Novo Purine Nucleotide Biosynthesis

Published:2018-02-09 Issue:5 Volume:61 Page:2027-2040
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ravindra Manasa¹,Wallace-Povirk Adrianne²,Karim Mohammad A.¹,Wilson Mike R.²,O’Connor Carrie²,White Kathryn²,Kushner Juiwanna²,Polin Lisa³²,George Christina²,Hou Zhanjun³²,Matherly Larry H.³²⁴,Gangjee Aleem¹^ORCID

Affiliation:

1. Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, Pennsylvania 15282, United States

2. Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan 48201, United States

3. Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, 421 East Canfield Street, Detroit, Michigan 48201, United States

4. Department of Pharmacology, Wayne State University School of Medicine, Detroit, Michigan 48201, United States

Funder

National Cancer Institute

Duquesne University

Eunice and Milton Ring Endowed Chair for Cancer Research

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b01708

Reference44 articles.

1. The Antifolates

2. The human proton-coupled folate transporter

3. Human reduced folate carrier: translation of basic biology to cancer etiology and therapy

4. The Major Facilitative Folate Transporters Solute Carrier 19A1 and Solute Carrier 46A1: Biology and Role in Antifolate Chemotherapy of Cancer

5. The folate receptor: What does it promise in tissue-targeted therapeutics?

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