Exploiting the S4–S5 Specificity of Human Neutrophil Proteinase 3 to Improve the Potency of Peptidyl Di(chlorophenyl)-phosphonate Ester Inhibitors: A Kinetic and Molecular Modeling Analysis-Reference-Cited by-同舟云学术

Exploiting the S4–S5 Specificity of Human Neutrophil Proteinase 3 to Improve the Potency of Peptidyl Di(chlorophenyl)-phosphonate Ester Inhibitors: A Kinetic and Molecular Modeling Analysis

Published:2018-02-14 Issue:5 Volume:61 Page:1858-1870
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Guarino Carla¹,Gruba Natalia²,Grzywa Renata³,Dyguda-Kazimierowicz Edyta⁴^ORCID,Hamon Yveline¹,Łȩgowska Monika²,Skoreński Marcin³,Dallet-Choisy Sandrine¹,Marchand-Adam Sylvain¹,Kellenberger Christine⁵,Jenne Dieter E.⁶,Sieńczyk Marcin³,Lesner Adam²^ORCID,Gauthier Francis¹,Korkmaz Brice¹^ORCID

Affiliation:

1. INSERM UMR1100, “Centre d’Etude des Pathologies Respiratoires”, Université de Tours, 37032 Tours, France

2. Faculty of Chemistry, University of Gdansk, Wita Stwosza 63, 80-308 Gdansk, Poland

3. Faculty of Chemistry, Division of Medicinal Chemistry and Microbiology, Wroclaw University of Science and Technology, Wyb. Wyspianskiego 27, 50-370 Wroclaw, Poland

4. Faculty of Chemistry, Advanced Materials Engineering and Modelling Group, Wroclaw University of Science and Technology, Wyb. Wyspianskiego 27, 50-370 Wroclaw, Poland

5. Architecture et Fonction des Macromolécules Biologiques, CNRS-Unité Mixte de Recherche (UMR), 13288 Marseille, France

6. Institute of Lung Biology and Disease, German Center for Lung Research (DZL), Comprehensive Pneumology Center Munich and Max Planck Institute of Neurobiology, 82152 Planegg-Martinsried, Germany

Funder

Ministerstwo Nauki i Szkolnictwa Wyzszego

European Regional Development Fund

Minist?re de l'Enseignement Sup?rieur et de la Recherche

Politechnika Wroclawska

Association Vaincre la Mucoviscidose

Alexander von Humboldt-Stiftung

R?gion Centre-Val de Loire

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine