Optimization of Selective Mitogen-Activated Protein Kinase Interacting Kinases 1 and 2 Inhibitors for the Treatment of Blast Crisis Leukemia-Reference-Cited by-同舟云学术

Optimization of Selective Mitogen-Activated Protein Kinase Interacting Kinases 1 and 2 Inhibitors for the Treatment of Blast Crisis Leukemia

Published:2018-04-23 Issue:10 Volume:61 Page:4348-4369
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Yang Haiyan¹,Chennamaneni Lohitha Rao²,Ho Melvyn Wai Tuck¹,Ang Shi Hua¹,Tan Eldwin Sum Wai¹,Jeyaraj Duraiswamy Athisayamani¹,Yeap Yoon Sheng¹,Liu Boping¹,Ong Esther Hq¹,Joy Joma Kanikadu¹,Wee John Liang Kuan¹,Kwek Perlyn¹,Retna Priya¹,Dinie Nurul¹,Nguyen Thuy Thi Hanh¹,Tai Shi Jing¹,Manoharan Vithya¹,Pendharkar Vishal¹,Low Choon Bing¹,Chew Yun Shan¹,Vuddagiri Susmitha¹,Sangthongpitag Kanda¹,Choong Meng Ling¹,Lee May Ann¹,Kannan Srinivasaraghavan³^ORCID,Verma Chandra S.³⁴⁵^ORCID,Poulsen Anders¹^ORCID,Lim Sharon⁶,Chuah Charles⁶,Ong Tiong Sin⁶⁷,Hill Jeffrey¹,Matter Alex¹,Nacro Kassoum¹^ORCID

Affiliation:

1. Experimental Therapeutics Centre (ETC), A*STAR, 31 Biopolis Way, Nanos #03-01, 138669 Singapore

2. Organic Chemistry, Institute of Chemical and Engineering Sciences (ICES), A*STAR, 8 Biomedical Grove, Neuros, #07-01, 138665 Singapore

3. Bioinformatics Institute (BII), A*STAR, 30 Biopolis Street, #07-01 Matrix, 138671 Singapore

4. School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, 637551 Singapore

5. Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, 117543 Singapore

6. Duke-NUS Medical School, 8 College Road, 169857 Singapore

7. Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, United States

Funder

Agency for Science, Technology and Research

Joint Council Office, Agency for Science, Technology and Research

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b01714

Reference75 articles.

1. Mnk kinase pathway: Cellular functions and biological outcomes

2. Mnk2 and Mnk1 Are Essential for Constitutive and Inducible Phosphorylation of Eukaryotic Initiation Factor 4E but Not for Cell Growth or Development

3. MNK kinases regulate multiple TLR pathways and innate proinflammatory cytokines in macrophages

4. Posttranscriptional regulation of TNFα expression via eukaryotic initiation factor 4E (eIF4E) phosphorylation in mouse macrophages

5. The Mnks Are Novel Components in the Control of TNFα Biosynthesis and Phosphorylate and Regulate hnRNP A1

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