Discovery of a para-Acetoxy-benzyl Ester Prodrug of a Hydroxamate-Based Glutamate Carboxypeptidase II Inhibitor as Oral Therapy for Neuropathic Pain
Author:
Affiliation:
1. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, vvi, 166 10 Prague, Czech Republic
2. Institute of Biotechnology, Academy of Sciences of the Czech Republic, vvi, 166 10 Prague, Czech Republic
Funder
National Cancer Institute
European Regional Development Fund
Ministerstvo ?kolstv?, Ml?de?e a Telov?chovy
Akademie Ved Cesk? Republiky
?stav organick? chemie a biochemie, Akademie ved Cesk? Republiky
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b00825
Reference22 articles.
1. Glutamate Carboxypeptidase II
2. Still NAAG’ing After All These Years
3. Glutamate Carboxypeptidase II in Diagnosis and Treatment of Neurologic Disorders and Prostate Cancer
4. Inhibition of spinal N-acetylated-α-linked acidic dipeptidase produces an antinociceptive effect in the rat formalin test
5. Spinal N-acetyl-α-linked acidic dipeptidase (NAALADase) inhibition attenuates mechanical allodynia induced by paw carrageenan injection in the rat
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