Disrupting Tryptophan in the Central Hydrophobic Region Selectively Mitigates Immunomodulatory Activities of the Innate Defence Regulator Peptide IDR-1002-Reference-Cited by-同舟云学术

Disrupting Tryptophan in the Central Hydrophobic Region Selectively Mitigates Immunomodulatory Activities of the Innate Defence Regulator Peptide IDR-1002

Published:2021-05-11 Issue:10 Volume:64 Page:6696-6705
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Piyadasa Hadeesha¹²³,Hemshekhar Mahadevappa¹,Osawa Natasha¹,Lloyd Dylan¹,Altieri Anthony¹²,Basu Sujata⁴⁵,Krokhin Oleg V.¹^ORCID,Halayko Andrew J.⁴⁵^ORCID,Mookherjee Neeloffer¹²⁵^ORCID

Affiliation:

1. Manitoba Centre for Proteomics and Systems Biology, Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba R3E3P4, Canada

2. Department of Immunology, University of Manitoba, Winnipeg, Manitoba R3E0T5, Canada

3. Department of Pathology, School of Medicine, Stanford University, Palo Alto, California 94304, United States

4. Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, Manitoba R3E0J9, Canada

5. Biology of Breathing Group, The Children’s Hospital Research Institute of Manitoba, Winnipeg, Manitoba R3E3P4, Canada

Funder

Canadian Institutes of Health Research

AllerGen

Canada Research Chairs

Research Manitoba

Children?s Hospital Research Institute of Manitoba

Canadian Respiratory Research Network

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c02065

Reference40 articles.

1. Multiple Immune-Modulatory Functions Of Cathelicidin Host Defense Peptides

2. Human cathelicidin LL-37 and its derivative IG-19 regulate interleukin-32-induced inflammation

3. Reassessing the Host Defense Peptide Landscape

4. Functions of Cationic Host Defense Peptides in Immunity

5. Antimicrobial host defence peptides: functions and clinical potential

Cited by 5 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Biological Sex Is an Effect Modifier of Allergen-Mediated Alteration of the Lung Proteome;Journal of Proteome Research;2024-08-30

2. IFNγ-mediated IL-33 production is dependent on the aryl hydrocarbon receptor in human bronchial epithelial cells;Cytokine;2023-12

3. Combination of IL-17A/F and TNF-α uniquely alters the bronchial epithelial cell proteome to enhance proteins that augment neutrophil migration;Journal of Inflammation;2022-12-14

4. Role of Anti-Cancer Peptides as Immunomodulatory Agents: Potential and Design Strategy;Pharmaceutics;2022-12-01

5. Immunobiology of Steroid-Unresponsive Severe Asthma;Frontiers in Allergy;2021-08-27