Conformational Constraint between Aromatic Residue Side Chains in the “Message” Sequence of the Peptide Arodyn Using Ring Closing Metathesis Results in a Potent and Selective Kappa Opioid Receptor Antagonist-Reference-Cited by-同舟云学术

Conformational Constraint between Aromatic Residue Side Chains in the “Message” Sequence of the Peptide Arodyn Using Ring Closing Metathesis Results in a Potent and Selective Kappa Opioid Receptor Antagonist

Published:2021-03-10 Issue:6 Volume:64 Page:3153-3164
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Gisemba Solomon A.¹²,Ferracane Michael J.²³^ORCID,Murray Thomas F.⁴^ORCID,Aldrich Jane V.¹²^ORCID

Affiliation:

1. Department of Medicinal Chemistry, The University of Kansas, Lawrence, Kansas 66045, United States

2. Department of Medicinal Chemistry, University of Florida, Gainesville, Florida 32610, United States

3. Department of Chemistry, University of Redlands, Redlands, California 92373, United States

4. Departments of Pharmacology and Neuroscience, School of Medicine, Creighton University, Omaha, Nebraska 68102, United States

Funder

National Institute on Drug Abuse

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c01984

Reference46 articles.

1. Development of κ Opioid Receptor Antagonists

2. Long-acting κ opioid antagonists nor-BNI, GNTI and JDTic: pharmacokinetics in mice and lipophilicity

3. Long-Acting κ Opioid Antagonists Disrupt Receptor Signaling And Produce Noncompetitive Effects By Activating C-Jun N-Terminal Kinase

4. Behavioral Pharmacology of Novel Kappa Opioid Receptor Antagonists in Rats

5. Zyklophin, a systemically active selective kappa opioid receptor peptide antagonist with short duration of action

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