Design, Synthesis, and Biological Evaluation of Covalent Inhibitors of Focal Adhesion Kinase (FAK) against Human Malignant Glioblastoma

Author:

Li Bo1,Li Yongliang2,Tomkiewicz-Raulet Céline3,Dao Pascal4,Lietha Daniel5,Yen-Pon Expédite1,Du Zhiyun2,Coumoul Xavier3,Garbay Christiane1,Etheve-Quelquejeu Mélanie1,Chen Huixiong1ORCID

Affiliation:

1. Chemistry of RNA, Nucleosides, Peptides and Heterocycles, CNRS UMR8601, Université de Paris, 45 rue des Saints-Pères, 75006 Paris, France

2. School of Chemical Engineering and Light Industry, Guangdong University of Technology, No. 100 Waihuan Xi Road, Education Mega Center, Guangzhou 510006, China

3. Toxicologie, Pharmacologie et Signalisation Cellulaire, INSERM, UMR S 1124, Université de Paris, 45 rue des Saints-Pères, 75006 Paris, France

4. Université Côte d’Azur, CNRS, Institut de Chimie de Nice UMR7272, 06108 Nice, France

5. Cell Signalling and Adhesion Group, Structural and Chemical Biology, Biological Research Center (CIB), Spanish National Research Council (CSIC), Calle Ramiro de Maeztu, Madrid 28040, Spain

Funder

Ministerio de Ciencia, Innovaci?n y Universidades

European Regional Development Fund

Ministerio de Econom?a y Competitividad

China Scholarship Council

National Natural Science Foundation of China

la Ligue contre le cancer Paris Ile-de-France

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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