Structural Basis for EGFR Mutant Inhibition by Trisubstituted Imidazole Inhibitors-Reference-Cited by-同舟云学术

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Structural Basis for EGFR Mutant Inhibition by Trisubstituted Imidazole Inhibitors

Published:2020-04-03 Issue:8 Volume:63 Page:4293-4305
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Heppner David E.¹²^ORCID,Günther Marcel³,Wittlinger Florian³,Laufer Stefan A.³^ORCID,Eck Michael J.¹²

Affiliation:

1. Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, United States

2. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United States

3. Institute for Pharmaceutical Sciences, Eberhard Karls Universität Tübingen, Tübingen 72076, Germany

Funder

National Cancer Institute

Deutsche Forschungsgemeinschaft

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c00200

Reference36 articles.

1. EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy

2. Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non–Small-Cell Lung Cancer to Gefitinib

3. The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP

4. EGFRMutation and Resistance of Non–Small-Cell Lung Cancer to Gefitinib

5. Novel mutant-selective EGFR kinase inhibitors against EGFR T790M

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