Structure–Activity Relationship Studies on Oxazolo[3,4-a]pyrazine Derivatives Leading to the Discovery of a Novel Neuropeptide S Receptor Antagonist with Potent In Vivo Activity-Reference-Cited by-同舟云学术

Structure–Activity Relationship Studies on Oxazolo[3,4-a]pyrazine Derivatives Leading to the Discovery of a Novel Neuropeptide S Receptor Antagonist with Potent In Vivo Activity

Published:2021-03-18 Issue:7 Volume:64 Page:4089-4108
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Albanese Valentina¹,Ruzza Chiara²³,Marzola Erika¹,Bernardi Tatiana¹,Fabbri Martina¹,Fantinati Anna¹,Trapella Claudio¹³,Reinscheid Rainer K.⁴⁵,Ferrari Federica²,Sturaro Chiara²,Calò Girolamo⁶,Amendola Giorgio⁷^ORCID,Cosconati Sandro⁷^ORCID,Pacifico Salvatore¹^ORCID,Guerrini Remo¹³,Preti Delia¹^ORCID

Affiliation:

1. Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Via Luigi Borsari 46, 44121 Ferrara, Italy

2. Department of Neuroscience and Rehabilitation, Section of Pharmacology, University of Ferrara, Via Fossato di Mortara 17/19, 44121 Ferrara, Italy

3. LTTA Laboratory for Advanced Therapies, Technopole of Ferrara, 44121 Ferrara, Italy

4. Institute of Pharmacology and Toxicology, Jena University Hospital, Friedrich Schiller University, 07747 Jena, Germany

5. Institute of Physiology I, University Hospital Münster, University of Münster, 48149 Münster, Germany

6. Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Largo Meneghetti, 2, 35131 Padova, Italy

7. “DiSTABiF”, Università della Campania “Luigi Vanvitelli”, Via Vivaldi 43, 81100 Caserta, Italy

Funder

Universit? degli Studi di Ferrara

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c02223

Reference70 articles.

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2. Neuropeptide S

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4. Distribution of neuropeptide S receptor mRNA and neurochemical characteristics of neuropeptide S-expressing neurons in the rat brain

5. Anatomical characterization of the neuropeptide S system in the mouse brain by in situ hybridization and immunohistochemistry

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