Two for the Price of One: Heterobivalent Ligand Design Targeting Two Binding Sites on Voltage-Gated Sodium Channels Slows Ligand Dissociation and Enhances Potency-Reference-Cited by-同舟云学术

Two for the Price of One: Heterobivalent Ligand Design Targeting Two Binding Sites on Voltage-Gated Sodium Channels Slows Ligand Dissociation and Enhances Potency

Published:2020-10-20 Issue:21 Volume:63 Page:12773-12785
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Peschel Alicia¹,Cardoso Fernanda C.¹^ORCID,Walker Andrew A.¹^ORCID,Durek Thomas¹,Stone M. Rhia L.¹,Braga Emidio Nayara¹^ORCID,Dawson Philip E.²^ORCID,Muttenthaler Markus¹³^ORCID,King Glenn F.¹^ORCID

Affiliation:

1. Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD 4072, Australia

2. Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States

3. Institute of Biological Chemistry, Faculty of Chemistry, University of Vienna, 1090 Vienna, Austria

Funder

National Health and Medical Research Council

Australian Research Council

H2020 European Research Council

University of Queensland

Publisher

American Chemical Society (ACS)

Subject