Lead Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series for the Treatment of Malaria-Reference-Cited by-同舟云学术

Lead Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series for the Treatment of Malaria

Published:2020-04-06 Issue:9 Volume:63 Page:4929-4956
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kokkonda Sreekanth¹,Deng Xiaoyi²,White Karen L.³,El Mazouni Farah²,White John¹,Shackleford David M.³,Katneni Kasiram³,Chiu Francis C. K.³,Barker Helena³,McLaren Jenna³,Crighton Elly³,Chen Gong³,Angulo-Barturen Inigo⁴,Jimenez-Diaz Maria Belen⁴,Ferrer Santiago⁴,Huertas-Valentin Leticia⁴,Martinez-Martinez Maria Santos⁴,Lafuente-Monasterio Maria Jose⁴,Chittimalla Rajesh⁵,Shahi Shatrughan P.⁵,Wittlin Sergio⁶⁷,Waterson David⁸,Burrows Jeremy N.⁸,Matthews Dave⁸,Tomchick Diana⁹,Rathod Pradipsinh K.¹,Palmer Michael J.⁸,Charman Susan A.³,Phillips Margaret A.²^ORCID

Affiliation:

1. Departments of Chemistry and Global Health, University of Washington, Seattle, Washington 98195, United States

2. Departments of Biochemistry, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, Texas 75390-9135, United States

3. Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia

4. GSK, Tres Cantos Medicines Development Campus, Severo Ochoa, Madrid 28760, Spain

5. Syngene International Ltd, Bangalore 560 099, India

6. Swiss Tropical and Public Health Institute, Socinstrasse 57, 4002 Basel, Switzerland

7. University of Basel, 4002 Basel, Switzerland

8. Medicines for Malaria Venture, 1215 Geneva, Switzerland

9. Department of Biophysics, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, Texas 75390-9135, United States

Funder

Welch Foundation

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

Medicines for Malaria Venture

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c00311

Reference55 articles.

1. World Health Organization. Leading Causes of Death. https://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death (accessed Feb 27, 2020).

2. World Health Organization. World Malaria Report 2019. ISBN: 978-92-4-156572-1, Geneva, Switzerland, 2019.

3. Malaria biology and disease pathogenesis: insights for new treatments

4. Malaria

5. Malaria

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