Synthesis of Guaianolide Analogues with a Tunable α-Methylene−γ-lactam Electrophile and Correlating Bioactivity with Thiol Reactivity-Reference-Cited by-同舟云学术

Synthesis of Guaianolide Analogues with a Tunable α-Methylene−γ-lactam Electrophile and Correlating Bioactivity with Thiol Reactivity

Published:2020-11-17 Issue:23 Volume:63 Page:14951-14978
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Jackson Paul A.¹,Schares Henry A. M.²,Jones Katherine F. M.³,Widen John C.²,Dempe Daniel P.¹,Grillet Francois¹,Cuellar Matthew E.²⁴^ORCID,Walters Michael A.²⁴^ORCID,Harki Daniel A.²³^ORCID,Brummond Kay M.¹^ORCID

Affiliation:

1. Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States

2. Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States

3. Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States

4. Institute for Therapeutics Discovery and Development, University of Minnesota, Minneapolis, Minnesota 55455, United States

Funder

National Cancer Institute

University of Pittsburgh

National Institute of General Medical Sciences

National Science Foundation

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c01464

Reference68 articles.

1. The Renaissance of α-Methylene-γ-butyrolactones: New Synthetic Approaches

2. Guaianolide Sesquiterpenoids: Pharmacology and Biosynthesis

3. Guaianolides in apiaceae: perspectives on pharmacology and biosynthesis

4. What made sesquiterpene lactones reach cancer clinical trials?

5. Synthesis and antileukemic activities of C1–C10-modified parthenolide analogues

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