Intestinal Excretion, Intestinal Recirculation, and Renal Tubule Reabsorption Are Underappreciated Mechanisms That Drive the Distribution and Pharmacokinetic Behavior of Small Molecule Drugs-Reference-Cited by-同舟云学术

Intestinal Excretion, Intestinal Recirculation, and Renal Tubule Reabsorption Are Underappreciated Mechanisms That Drive the Distribution and Pharmacokinetic Behavior of Small Molecule Drugs

Published:2021-05-19 Issue:11 Volume:64 Page:7045-7059
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Zhang Donglu¹^ORCID,Wei Cong²,Hop Cornelis E. C. A.¹,Wright Matthew R.¹,Hu Ming³,Lai Yurong⁴^ORCID,Khojasteh S. Cyrus¹,Humphreys W. Griff⁵

Affiliation:

1. Department of Drug Metabolism and Pharmacokinetics, Genentech, 1 DNA Way, South San Francisco, California 94080, United States,

2. Drug Metabolism and Pharmacokinetics, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States,

3. University of Houston College of Pharmacy, 4849 Calhoun Road, Houston, Texas 77204, United States,

4. Drug Metabolism and Pharmacokinetics, Gilead Sciences, 333 Lakeside Drive, Foster City, California 94404, United States,

5. Aranmore Pharma Consulting, 11 Andrew Drive, Lawrenceville, New Jersey 08648, United States,

Funder

National Cancer Institute

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c01720

Reference148 articles.

1. Intestinal Excretion of Unconjugated Bilirubin in Man and Rats with Inherited Unconjugated Hyperbilirubinemia

2. Direct Intestinal Cholesterol Secretion Contributes Significantly to Total Fecal Neutral Sterol Excretion in Mice

3. Substantial excretion of digoxin via the intestinal mucosa and prevention of long-term digoxin accumulation in the brain by the mdrla P-glycoprotein

4. Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

5. Intestinal secretion of intravenous talinolol is inhibited by luminal R-verapamil*

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