Identification and Optimization of a Series of 8-Hydroxy Naphthyridines with Potent In Vitro Antileishmanial Activity: Initial SAR and Assessment of In Vivo Activity-Reference-Cited by-同舟云学术

Identification and Optimization of a Series of 8-Hydroxy Naphthyridines with Potent In Vitro Antileishmanial Activity: Initial SAR and Assessment of In Vivo Activity

Published:2020-07-14 Issue:17 Volume:63 Page:9523-9539
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Thomas Michael G.¹^ORCID,De Rycker Manu¹^ORCID,Wall Richard J.¹,Spinks Daniel¹,Epemolu Ola¹,Manthri Sujatha¹,Norval Suzanne¹,Osuna-Cabello Maria¹,Patterson Stephen¹,Riley Jennifer¹,Simeons Frederick R. C.¹,Stojanovski Laste¹,Thomas John¹,Thompson Stephen¹,Naylor Claire¹,Fiandor Jose M.²,Wyatt Paul G.¹^ORCID,Marco Maria²^ORCID,Wyllie Susan¹^ORCID,Read Kevin D.¹^ORCID,Miles Timothy J.²^ORCID,Gilbert Ian H.¹^ORCID

Affiliation:

1. Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom

2. Global Health R&D, GlaxoSmithKline, Tres Cantos 28760, Spain

Funder

Wellcome

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c00705

Reference26 articles.

1. Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need

2. Injectable Paromomycin for Visceral Leishmaniasis in India

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