Optimization of Truncated Glucagon Peptides to Achieve Selective, High Potency, Full Antagonists-Reference-Cited by-同舟云学术

Optimization of Truncated Glucagon Peptides to Achieve Selective, High Potency, Full Antagonists

Published:2021-04-06 Issue:8 Volume:64 Page:4697-4708
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Yang Bin¹²,Gelfanov Vasily M.¹²,Perez-Tilve Diego³,DuBois Barent²,Rohlfs Rebecca²,Levy Jay²,Douros Jonathan D.²,Finan Brian²,Mayer John P.¹,DiMarchi Richard D.¹^ORCID

Affiliation:

1. Department of Chemistry, Indiana University, Bloomington, Indiana 47405, United States

2. Novo Nordisk Research Center Indianapolis, Indianapolis, Indiana 46241, United States

3. Department of Medicine, University of Cincinnati, Cincinnati, Ohio 45267, United States

Funder

Indiana University

Marcadia Biotech, Inc.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c02069

Reference54 articles.

1. Hyperglycemia of Diabetic Rats Decreased by a Glucagon Receptor Antagonist

2. Glucagon receptor antagonism improves islet function in mice with insulin resistance induced by a high-fat diet

3. A Novel Glucagon Receptor Antagonist, NNC 25-0926, Blunts Hepatic Glucose Production in the Conscious Dog

4. Effects of a novel glucagon receptor antagonist (Bay 27-9955) on glucagon-stimulated glucose production in humans

5. Short-term administration of the glucagon receptor antagonist LY2409021 lowers blood glucose in healthy people and in those with type 2 diabetes

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