Discovery of a First-In-Class Small Molecule Antagonist against the Adrenomedullin-2 Receptor: Structure–Activity Relationships and Optimization-Reference-Cited by-同舟云学术

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Discovery of a First-In-Class Small Molecule Antagonist against the Adrenomedullin-2 Receptor: Structure–Activity Relationships and Optimization

Published:2021-03-05 Issue:6 Volume:64 Page:3299-3319
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Zirimwabagabo Jean-Olivier¹^ORCID,Jailani Ameera B. A.²^ORCID,Avgoustou Paris²^ORCID,Tozer Matthew J.³^ORCID,Gibson Karl R.⁴^ORCID,Glossop Paul A.⁴^ORCID,Mills James E. J.⁴^ORCID,Porter Roderick A.⁵^ORCID,Blaney Paul⁶^ORCID,Wang Ning²^ORCID,Skerry Timothy M.²^ORCID,Richards Gareth O.²^ORCID,Harrity Joseph P. A.¹^ORCID

Affiliation:

1. Department of Chemistry, University of Sheffield, Sheffield S10 2TN, U.K.

2. Department of Oncology and Metabolism, University of Sheffield, Sheffield S10 2TN, U.K.

3. Matt Tozer Consultancy, Bognor Regis PO21 1DY, U.K.

4. Sandexis Medicinal Chemistry Ltd., Sandwich, Kent CT13 9ND, U.K.

5. Rod Porter Consultancy, Ashwell, Hertfordshire SG7 5PG, U.K.

6. Concept Life Sciences, High Peak SK23 0PG, U.K.

Funder

Prostate Cancer UK

University of Sheffield

Wellcome Trust

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c02191

Reference47 articles.

1. THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein‐coupled receptors

2. G Protein-Coupled Receptors as Targets for Approved Drugs: How Many Targets and How Many Drugs?

3. Receptor Activity-modifying Protein-directed G Protein Signaling Specificity for the Calcitonin Gene-related Peptide Family of Receptors

4. Receptor Activity-Modifying Proteins (RAMPs): New Insights and Roles

5. Update on the pharmacology of calcitonin/CGRP family of peptides: IUPHAR Review 25

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2. Peptidergic Systems and Cancer: Focus on Tachykinin and Calcitonin/Calcitonin Gene-Related Peptide Families;Cancers;2023-03-09

3. Targeting the adrenomedullin-2 receptor for the discovery and development of novel anti-cancer agents;Expert Opinion on Drug Discovery;2022-06-22

4. Accelerated Development With Increased Bone Mass and Skeletal Response to Loading Suggest Receptor Activity Modifying Protein-3 as a Bone Anabolic Target;Frontiers in Endocrinology;2022-01-12

5. Asymmetric Dieckmann Condensation towards Spirocyclic Oxindoles Catalyzed by Amino Acid‐Derived Phosphonium Salts;Advanced Synthesis & Catalysis;2021-11-16

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