Discovery and Optimization of Non-bile Acid FXR Agonists as Preclinical Candidates for the Treatment of Nonalcoholic Steatohepatitis-Reference-Cited by-同舟云学术

Discovery and Optimization of Non-bile Acid FXR Agonists as Preclinical Candidates for the Treatment of Nonalcoholic Steatohepatitis

Published:2020-09-29 Issue:21 Volume:63 Page:12748-12772
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Li Junyou¹²,Liu Mengqi¹²,Li Yazhou¹³,Sun Dan-dan¹,Shu Zhihao¹,Tan Qian¹,Guo Shimeng¹³,Xie Rongrong¹,Gao Lixin¹,Ru Hongbo¹,Zang Yi¹²,Liu Hong¹²^ORCID,Li Jia¹²⁴,Zhou Yu¹²^ORCID

Affiliation:

1. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China

2. University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China

3. School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210046, China

4. Open Studio for Druggability Research of Marine Natural Products, Pilot National Laboratory for Marine Science and Technology (Qingdao), 1 Wenhai Road, Aoshanwei, Jimo, Qingdao 266237, China

Funder

Ministry of Science and Technology of the People's Republic of China

K. C. Wong Education Foundation

National Natural Science Foundation of China

Shanghai Municipality

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c01065

Reference56 articles.