Tricyclic-Carbocyclic RORγt Inverse Agonists—Discovery of BMS-986313-Reference-Cited by-同舟云学术

Tricyclic-Carbocyclic RORγt Inverse Agonists—Discovery of BMS-986313

Published:2021-02-16 Issue:5 Volume:64 Page:2714-2724
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Yang Michael G.¹^ORCID,Beaudoin-Bertrand Myra¹,Xiao Zili¹,Marcoux David¹^ORCID,Weigelt Carolyn A.¹,Yip Shiuhang¹,Wu Dauh-Rurng¹,Ruzanov Max¹,Sack John S.¹,Wang Jinhong¹,Yarde Melissa¹,Li Sha¹,Shuster David J.¹,Xie Jenny H.¹,Sherry Tara¹,Obermeier Mary T.¹,Fura Aberra¹,Stefanski Kevin¹,Cornelius Georgia¹,Khandelwal Purnima¹,Karmakar Ananta²^ORCID,Basha Mushkin²,Babu Venkatesh²,Gupta Arun Kumar²,Mathur Arvind¹,Salter-Cid Luisa¹,Denton Rex¹,Zhao Qihong¹,Dhar T. G. Murali¹^ORCID

Affiliation:

1. Research and Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543-4000, United States

2. Department of Discovery Synthesis, Biocon Bristol-Myers Squibb Research Centre, Biocon Park, Bommasandra IV Phase, Jigani Link Road, Bengaluru 560099, India

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c01992

Reference31 articles.

1. Small molecule inhibitors of RORγt: Targeting Th17 cells and other applications

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4. An essential function for the nuclear receptor RORγt in the generation of fetal lymphoid tissue inducer cells

5. The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells

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