Discovery of Potent, Highly Selective, and In Vivo Efficacious, Allosteric MALT1 Inhibitors by Iterative Scaffold Morphing-Reference-Cited by-同舟云学术

Discovery of Potent, Highly Selective, and In Vivo Efficacious, Allosteric MALT1 Inhibitors by Iterative Scaffold Morphing

Published:2020-11-30 Issue:23 Volume:63 Page:14576-14593
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Pissot Soldermann Carole¹^ORCID,Simic Oliver¹,Renatus Martin¹,Erbel Paulus¹,Melkko Samu¹,Wartmann Markus¹,Bigaud Marc¹,Weiss Andreas¹,McSheehy Paul²,Endres Ralf,Santos Paulo,Blank Jutta¹,Schuffenhauer Ansgar¹^ORCID,Bold Guido¹,Buschmann Nicole¹,Zoller Thomas¹,Altmann Eva¹^ORCID,Manley Paul W.¹,Dix Ina¹,Buchdunger Elisabeth¹,Scesa Julien¹,Quancard Jean¹,Schlapbach Achim¹,Bornancin Frédéric¹,Radimerski Thomas²,Régnier Catherine H.¹

Affiliation:

1. Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002 Basel, Switzerland

2. Basilea Pharmaceutica, CH-4002 Basel, Switzerland

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c01245

Reference25 articles.

1. Identification of Paracaspases and Metacaspases Two Ancient Families of Caspase-like Proteins, One of which Plays a Key Role in MALT Lymphoma

2. Holding All the CARDs: How MALT1 Controls CARMA/CARD-Dependent Signaling