Scalable Synthesis, In Vitro cccDNA Reduction, and In Vivo Antihepatitis B Virus Activity of a Phosphonomethoxydeoxythreosyl Adenine Prodrug-Reference-Cited by-同舟云学术

Scalable Synthesis, In Vitro cccDNA Reduction, and In Vivo Antihepatitis B Virus Activity of a Phosphonomethoxydeoxythreosyl Adenine Prodrug

Published:2020-11-16 Issue:22 Volume:63 Page:13851-13860
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Luo Min¹,Wu Shuo²,Kalkeri Raj³,Ptak Roger G.³,Zhou Tianlun⁴,Van Mellaert Lieve⁵,Wang Chuanmin⁶,Dumbre Shrinivas G.¹,Block Timothy⁴,Groaz Elisabetta¹,De Jonghe Steven⁷^ORCID,Li Yuhuan²,Herdewijn Piet¹^ORCID

Affiliation:

1. Medicinal Chemistry, KU Leuven, Rega Institute for Medical Research, Herestraat 49-box 1041, 3000 Leuven, Belgium

2. CAMS Key Laboratory of Antiviral Drug Research, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1, Tiantan Xili, 100050 Beijing, China

3. Department of Infectious Disease Research, Southern Research Institute, 431 Aviation Way, Frederick, Maryland 21701, United States

4. Baruch S. Blumberg Institute, Doylestown, Pennsylvania 18902, United States

5. Department of Microbiology, Immunology and Transplantation, Laboratory of Molecular Bacteriology, KU Leuven, Rega Institute for Medical Research, Herestraat 49-box 1037, 3000 Leuven, Belgium

6. Department of Infectious Diseases, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, China

7. Department of Microbiology, Immunology and Transplantation, Laboratory of Virology and Chemotherapy, KU Leuven, Rega Institute for Medical Research, Herestraat 49-box 1043, 3000 Leuven, Belgium

Funder

KU Leuven

National Institute of Allergy and Infectious Diseases

The Drug Innovation Major Project

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c01381

Reference35 articles.

1. World Health Organization About Viral Hepatitis. 2019. WHO, https://www.who.int/hepatitis/about/en/ (accessed Nov 28, 2020).web