Discovery and Optimization of Novel SUCNR1 Inhibitors: Design of Zwitterionic Derivatives with a Salt Bridge for the Improvement of Oral Exposure-Reference-Cited by-同舟云学术

Discovery and Optimization of Novel SUCNR1 Inhibitors: Design of Zwitterionic Derivatives with a Salt Bridge for the Improvement of Oral Exposure

Published:2020-08-28 Issue:17 Volume:63 Page:9856-9875
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Velcicky Juraj¹^ORCID,Wilcken Rainer¹^ORCID,Cotesta Simona¹,Janser Philipp¹,Schlapbach Achim¹,Wagner Trixie¹,Piechon Philippe¹,Villard Frederic¹,Bouhelal Rochdi¹,Piller Fabian¹,Harlfinger Stephanie¹,Stringer Rowan¹,Fehlmann Dominique¹,Kaupmann Klemens¹,Littlewood-Evans Amanda¹,Haffke Matthias¹,Gommermann Nina¹

Affiliation:

1. Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland

Funder

Novartis Institutes for BioMedical Research Inc

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c01020

Reference48 articles.

1. Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors