Design and Optimization of an Acyclic Amine Series of TRPV4 Antagonists by Electronic Modulation of Hydrogen Bond Interactions-Reference-Cited by-同舟云学术

Design and Optimization of an Acyclic Amine Series of TRPV4 Antagonists by Electronic Modulation of Hydrogen Bond Interactions

Published:2020-11-17 Issue:23 Volume:63 Page:14867-14884
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Patterson Jaclyn R.¹^ORCID,Terrell Lamont R.²,Donatelli Carla A.¹,Holt Dennis A.¹,Jolivette Larry J.¹,Rivero Ralph A.²,Roethke Theresa J.¹,Shu Arthur²,Stoy Patrick¹,Ye Guosen¹,Youngman Mark²,Lawhorn Brian G.¹^ORCID

Affiliation:

1. Heart Failure Discovery Performance Unit, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States

2. Flexible Discovery Unit, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c01303

Reference27 articles.

1. Molecular Determinants of Permeation through the Cation Channel TRPV4

2. Small Molecule Agonists and Antagonists of TRPV4

3. Recent advances in TRPV4 agonists and antagonists

4. TRPV4 Agonists and Antagonists

5. An Orally Active TRPV4 Channel Blocker Prevents and Resolves Pulmonary Edema Induced by Heart Failure

Cited by 9 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Synthesis, mesomorphic and fluorescent properties of 1,3,4-oxadiazoles/thiadiazoles with a terminal 3-fluoro-4-cyanophenyl group;Tetrahedron;2023-09

2. Design, Synthesis, and Bioactivity of Aldisine Derivatives Containing Oxime and Hydrazine Moieties Based on Hydrogen Bonds;Journal of Agricultural and Food Chemistry;2023-07-13

3. Transient Receptor Potential Vanilloid (TRPV4) channel inhibition: A novel promising approach for the treatment of lung diseases;Biomedicine & Pharmacotherapy;2023-07

4. Discovery of Aldisine and Its Derivatives as Novel Antiviral, Larvicidal, and Antiphytopathogenic-Fungus Agents;Journal of Agricultural and Food Chemistry;2022-09-21

5. Mono‐ N ‐Alkylation of Sulfonamides with Alcohols Catalyzed by Iridium N ‐Heterocyclic Carbene‐Phosphine Complexes;Asian Journal of Organic Chemistry;2022-06-21