Tetrahydroquinoline-Capped Histone Deacetylase 6 Inhibitor SW-101 Ameliorates Pathological Phenotypes in a Charcot–Marie–Tooth Type 2A Mouse Model-Reference-Cited by-同舟云学术

Tetrahydroquinoline-Capped Histone Deacetylase 6 Inhibitor SW-101 Ameliorates Pathological Phenotypes in a Charcot–Marie–Tooth Type 2A Mouse Model

Published:2021-04-08 Issue:8 Volume:64 Page:4810-4840
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Shen Sida¹^ORCID,Picci Cristina²,Ustinova Kseniya³,Benoy Veronick⁴,Kutil Zsófia³,Zhang Guiping¹^ORCID,Tavares Maurício T.¹^ORCID,Pavlíček Jiří³,Zimprich Chad A.⁵,Robers Matthew B.⁵,Van Den Bosch Ludo⁴,Bařinka Cyril³^ORCID,Langley Brett²,Kozikowski Alan P.⁶

Affiliation:

1. Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, United States

2. School of Health, The University of Waikato, Private Bag 3105, Hamilton 3240, New Zealand

3. Institute of Biotechnology of the Czech Academy of Sciences, 252 50 Vestec, Czech Republic

4. Laboratory of Neurobiology, Center for Brain & Disease (VIB) and Leuven Brain Institute (LBI), KU Leuven, B-3000 Leuven, Belgium

5. Promega Corporation, Madison, Wisconsin 53711, United States

6. Bright Minds Biosciences, Toronto, ON M5H 3V9, Canada

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c02210

Reference53 articles.

1. Why Hydroxamates May Not Be the Best Histone Deacetylase Inhibitors-What Some May Have Forgotten or Would Rather Forget?

2. Acetylation and deacetylation of non-histone proteins

3. Histone Deacetylase Inhibitors Modulating Non-epigenetic Players: The Novel Mechanism for Small Molecule Based Therapeutic Intervention

4. Histone deacetylases (HDACs): characterization of the classical HDAC family

5. The disordered N-terminus of HDAC6 is a microtubule-binding domain critical for efficient tubulin deacetylation

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