How a Fragment Draws Attention to Selectivity Discriminating Features between the Related Proteases Trypsin and Thrombin-Reference-Cited by-同舟云学术

How a Fragment Draws Attention to Selectivity Discriminating Features between the Related Proteases Trypsin and Thrombin

Published:2021-01-20 Issue:3 Volume:64 Page:1611-1625
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Sandner Anna¹,Ngo Khang¹,Schiebel Johannes¹,Pizarroso Angela Ilse Marca¹,Schmidt Linda¹,Wenzel Benjamin¹,Steinmetzer Torsten¹^ORCID,Ostermann Andreas²,Heine Andreas¹,Klebe Gerhard¹^ORCID

Affiliation:

1. Institut für Pharmazeutische Chemie, Philipps-Universität Marburg, Marbacher Weg 6, 35032 Marburg, Germany

2. Heinz Maier-Leibnitz Zentrum, Technische Universität München, Lichtenbergstraße 1, 85748 Garching, Germany

Funder

H2020 European Research Council

European Molecular Biology Organization

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c01809

Reference42 articles.

1. Trypsin Revisited

2. Small, noncovalent serine protease inhibitors

3. Oral, Direct Thrombin and Factor Xa Inhibitors: The Replacement for Warfarin, Leeches, and Pig Intestines?

4. pH and Concentrations of Pepsin and Trypsin in Feeding Tube Aspirates as Predictors of Tube Placement

5. Effects of Melagatran, a New Low-molecular-weight Thrombin Inhibitor, on Thrombin and Fibrinolytic Enzymes

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