Discovery of GLPG1972/S201086, a Potent, Selective, and Orally Bioavailable ADAMTS-5 Inhibitor for the Treatment of Osteoarthritis-Reference-Cited by-同舟云学术

Discovery of GLPG1972/S201086, a Potent, Selective, and Orally Bioavailable ADAMTS-5 Inhibitor for the Treatment of Osteoarthritis

Published:2021-03-15 Issue:6 Volume:64 Page:2937-2952
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Brebion Franck¹^ORCID,Gosmini Romain¹,Deprez Pierre¹,Varin Marie¹,Peixoto Christophe¹,Alvey Luke¹,Jary Hélène¹,Bienvenu Natacha¹,Triballeau Nicolas¹,Blanque Roland¹,Cottereaux Céline¹,Christophe Thierry²,Vandervoort Nele²,Mollat Patrick¹,Touitou Robert¹,Leonard Philip³,Ceuninck Frédéric De⁴,Botez Iuliana⁵,Monjardet Alain¹,van der Aar Ellen²,Amantini David¹

Affiliation:

1. Galapagos SASU, 102 Avenue Gaston Roussel, 93230 Romainville, France

2. Galapagos NV, Generaal De Wittelaan L11 A3, 2800 Mechelen, Belgium

3. Structural Biology, Charles River, Chesterford Research Park, CB10 1XL Saffron Walden, United Kingdom

4. Institut de Recherches Servier, Center for Therapeutic Innovation, Immuno-inflammatory Disease, 78290 Croissy sur Seine, France

5. Institut de Recherches Servier, Chemistry Center of Excellence, 78290 Croissy sur Seine, France

Funder

Servier

Galapagos NV

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c02008

Reference36 articles.

1. The individual and socioeconomic impact of osteoarthritis

2. Adverse Effects of Analgesics Commonly Used by Older Adults With Osteoarthritis: Focus on Non-Opioid and Opioid Analgesics

3. Osteoarthritis year in review 2015: imaging

4. ADAMTS and ADAM metalloproteinases in osteoarthritis – looking beyond the ‘usual suspects’

Cited by 39 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Prospects of Disease-Modifying Osteoarthritis Drugs;Rheumatic Disease Clinics of North America;2024-08

2. Increased mRNA expression of ADAMTS1 and ADAMTS4 in peripheral blood mononuclear cells of psoriasis patients developed psoriatic arthritis;Periodicum Biologorum;2024-06-19

3. The Versatility of Collagen in Pharmacology: Targeting Collagen, Targeting with Collagen;International Journal of Molecular Sciences;2024-06-13

4. Serum ARGS-aggrecan in a phase 2 clinical trial targeting osteoarthritis;Osteoarthritis and Cartilage;2024-06

5. BAY-9835: Discovery of the First Orally Bioavailable ADAMTS7 Inhibitor;Journal of Medicinal Chemistry;2024-02-13