Novel Piperidinyl-Azetidines as Potent and Selective CCR4 Antagonists Elicit Antitumor Response as a Single Agent and in Combination with Checkpoint Inhibitors-Reference-Cited by-同舟云学术

Novel Piperidinyl-Azetidines as Potent and Selective CCR4 Antagonists Elicit Antitumor Response as a Single Agent and in Combination with Checkpoint Inhibitors

Published:2020-07-15 Issue:15 Volume:63 Page:8584-8607
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Robles Omar¹,Jackson Jeffrey J.¹^ORCID,Marshall Lisa¹,Talay Oezcan¹,Chian David¹,Cutler Gene¹,Diokno Raymond¹,Hu Dennis X.¹,Jacobson Scott¹,Karbarz Emily¹,Kassner Paul D.¹,Ketcham John M.¹,McKinnell Jenny¹,Meleza Cesar¹,Reilly Maureen K.¹,Riegler Erin¹,Shunatona Hunter P.¹,Wadsworth Angela¹,Younai Ashkaan¹,Brockstedt Dirk G.¹,Wustrow David J.¹,Zibinsky Mikhail¹

Affiliation:

1. RAPT Therapeutics, 561 Eccles Avenue, South San Francisco, California 94080, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c00988

Reference41 articles.

1. Effector CD4 and CD8 T Cells and Their Role in the Tumor Microenvironment

2. Cancer immunotherapy: harnessing the immune system to battle cancer

3. Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy

4. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

Cited by 19 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Structurally Divergent Synthesis of Azetidines, 5,6‐Dihydro‐1,3‐oxazines and 2,3‐Dihydro‐1,4‐oxazines through Palladium‐Catalyzed Tandem Allylic Substitution Reaction;Chinese Journal of Chemistry;2024-07-16

2. A Narrative Review of the State of the Art of CCR4-Based Therapies in Cutaneous T-Cell Lymphomas: Focus on Mogamulizumab and Future Treatments;Antibodies;2024-04-22

3. Targeting tumor-infiltrating tregs for improved antitumor responses;Frontiers in Immunology;2024-03-04

4. Small molecule inhibitors targeting regulatory T cells for cancer treatment;European Journal of Immunology;2023-11-15

5. Design, synthesis and antitumor activity evaluation of tetrasubstituted pyrimidine derivatives containing methyl phenyl sulfone group;Medicinal Chemistry Research;2023-07-12