Deconstructing Noncovalent Kelch-like ECH-Associated Protein 1 (Keap1) Inhibitors into Fragments to Reconstruct New Potent Compounds

Author:

Pallesen Jakob S.1,Narayanan Dilip1,Tran Kim T.1,Solbak Sara M. Ø.1,Marseglia Giuseppe12,Sørensen Louis M. E.1,Høj Lars J.1,Munafò Federico1ORCID,Carmona Rosa M. C.1,Garcia Anthony D.13,Desu Haritha L.4,Brambilla Roberta45,Johansen Tommy N.1ORCID,Popowicz Grzegorz M.67,Sattler Michael67ORCID,Gajhede Michael1ORCID,Bach Anders1ORCID

Affiliation:

1. Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark

2. Food and Drug Department, University of Parma, Parco Area delle Scienze 27/a, 43124 Parma, Italy

3. École Nationale Supérieure de Chimie de Rennes, 11 Allée de Beaulieu, CS 50837, Rennes Cedex 7 35708, France

4. The Miami Project to Cure Paralysis, Dept. Neurological Surgery, University of Miami Miller School of Medicine, Miami, Florida 33136, United States

5. Department of Neurobiology Research, Institute of Molecular Medicine, and BRIDGE—Brain Research Inter Disciplinary Guided Excellence, Department of Clinical Research, University of Southern Denmark, DK-5000 Odense, Denmark

6. Institute of Structural Biology, Helmholtz Zentrum München, 85764 Neuherberg, Germany

7. Biomolecular NMR and Center for Integrated Protein Science Munich at Department of Chemistry, Technical University of Munich, 85747 Garching, Germany

Funder

Augustinus Fonden

A.P. Møller og Hustru Chastine Mc-Kinney Møllers Fond til almene Formaal

Hørslev-Fonden

Drug Research Academy, Københavns Universitet

Lundbeckfonden

Helmholtz-Center Munich

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3