Structure-Based Approaches to Improving Selectivity through Utilizing Explicit Water Molecules: Discovery of Selective β-Secretase (BACE1) Inhibitors over BACE2-Reference-Cited by-同舟云学术

Structure-Based Approaches to Improving Selectivity through Utilizing Explicit Water Molecules: Discovery of Selective β-Secretase (BACE1) Inhibitors over BACE2

Published:2021-03-15 Issue:6 Volume:64 Page:3075-3085
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Fujimoto Kazuki¹^ORCID,Yoshida Shuhei¹,Tadano Genta¹,Asada Naoya¹,Fuchino Kouki¹,Suzuki Shinji¹,Matsuoka Eriko¹,Yamamoto Takahiko¹,Yamamoto Shiho¹,Ando Shigeru²,Kanegawa Naoki²,Tonomura Yutaka²,Ito Hisanori³,Moechars Diederik⁴,Rombouts Frederik J. R.⁵^ORCID,Gijsen Harrie J. M.⁵^ORCID,Kusakabe Ken-ichi¹^ORCID

Affiliation:

1. Laboratory for Medicinal Chemistry Research, Shionogi Pharmaceutical Research Center, 1-1 Futaba-cho 3-chome, Toyonaka, Osaka 561-0825, Japan

2. Laboratory for Drug Discovery & Development, Shionogi Pharmaceutical Research Center, 1-1 Futaba-cho 3-chome, Toyonaka, Osaka 561-0825, Japan

3. Laboratory for Drug Discovery & Disease Research, Shionogi Pharmaceutical Research Center, 1-1 Futaba-cho 3-chome, Toyonaka, Osaka 561-0825, Japan

4. Neuroscience, Janssen Research & Development, Turnhoutseweg 30, B-2340 Beerse, Belgium

5. Discovery Sciences, Janssen Research & Development, Turnhoutseweg 30, B-2340 Beerse, Belgium

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c01858

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