Structural Analysis of Potent Hybrid HIV-1 Protease Inhibitors Containing Bis-tetrahydrofuran in a Pseudosymmetric Dipeptide Isostere-Reference-Cited by-同舟云学术

Structural Analysis of Potent Hybrid HIV-1 Protease Inhibitors Containing Bis-tetrahydrofuran in a Pseudosymmetric Dipeptide Isostere

Published:2020-07-16 Issue:15 Volume:63 Page:8296-8313
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Rusere Linah N.¹,Lockbaum Gordon J.¹^ORCID,Henes Mina¹,Lee Sook-Kyung²,Spielvogel Ean²,Rao Desaboini Nageswara¹,Kosovrasti Klajdi¹,Nalivaika Ellen A.¹,Swanstrom Ronald²,Kurt Yilmaz Nese¹^ORCID,Schiffer Celia A.¹^ORCID,Ali Akbar¹^ORCID

Affiliation:

1. Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, United States

2. Department of Biochemistry and Biophysics, and the UNC Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States

Funder

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c00529

Reference59 articles.

1. Current status and prospects of HIV treatment

2. Antiretroviral Drugs for Treatment and Prevention of HIV Infection in Adults

3. Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents with HIV; Department of Health and Human Services. Available at https://files.aidsinfo.nih.gov/contentfiles/lvguidelines/AdultandAdolescentGL.pdf. (Accessed February 15, 2020).

4. Molecular Basis for Drug Resistance in HIV-1 Protease

5. Recent Progress in the Development of HIV-1 Protease Inhibitors for the Treatment of HIV/AIDS

Cited by 7 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Unveiling Novel HIV-1 Protease Inhibitors through an Integrated Analysis of 3D-QSAR, Molecular Docking, and Binding Free Energy;Letters in Drug Design & Discovery;2024-06-03

2. HIV-1 protease inhibitors with a P1 phosphonate modification maintain potency against drug-resistant variants by increased interactions with flap residues;European Journal of Medicinal Chemistry;2023-09

3. Meet the Editorial Board Member;Current Medicinal Chemistry;2023-06

4. Beyond darunavir: recent development of next generation HIV-1 protease inhibitors to combat drug resistance;Chemical Communications;2022

5. Heterocyclic compounds as antiviral drugs: Synthesis, structure–activity relationship and traditional applications;Journal of Heterocyclic Chemistry;2021-08-12