Design, Synthesis, and Evaluation of New Quinazolinone Derivatives that Inhibit Bloom Syndrome Protein (BLM) Helicase, Trigger DNA Damage at the Telomere Region, and Synergize with PARP Inhibitors-Reference-Cited by-同舟云学术

Design, Synthesis, and Evaluation of New Quinazolinone Derivatives that Inhibit Bloom Syndrome Protein (BLM) Helicase, Trigger DNA Damage at the Telomere Region, and Synergize with PARP Inhibitors

Published:2020-07-22 Issue:17 Volume:63 Page:9752-9772
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wang Chen-Xi¹,Zhang Zi-Lin¹,Yin Qi-Kun¹,Tu Jia-Li¹,Wang Jia-En¹,Xu Yao-Hao¹,Rao Yong¹,Ou Tian-Miao¹^ORCID,Huang Shi-Liang¹,Li Ding¹^ORCID,Wang Hong-Gen¹^ORCID,Li Qing-Jiang¹^ORCID,Tan Jia-Heng¹^ORCID,Chen Shuo-Bin¹^ORCID,Huang Zhi-Shu¹^ORCID

Affiliation:

1. School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Sun Yat-sen University, Guangzhou 510006, China

Funder

State Administration of Foreign Experts Affairs

Ministry of Education of the People's Republic of China

National Natural Science Foundation of China

Natural Science Foundation of Guangdong Province

Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program

Guangdong Provincial Key Laboratory of Construction Foundation, Sun Yat-Sen University

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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