Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with In Vivo Efficacy in Multiple Myeloma-Reference-Cited by-同舟云学术

Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with In Vivo Efficacy in Multiple Myeloma

Published:2021-03-04 Issue:6 Volume:64 Page:3392-3426
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Rabal Obdulia¹,San José-Enériz Edurne²,Agirre Xabier²,Sánchez-Arias Juan Antonio¹,de Miguel Irene¹,Ordoñez Raquel²,Garate Leire²,Miranda Estíbaliz²,Sáez Elena¹,Vilas-Zornoza Amaia²,Pineda-Lucena Antonio¹,Estella Ander¹,Zhang Feifei³,Wu Wei³,Xu Musheng³,Prosper Felipe²⁴,Oyarzabal Julen¹^ORCID

Affiliation:

1. Small Molecule Discovery Platform, Molecular Therapeutics Program, Center for Applied Medical Research (CIMA), University of Navarra, Avenida Pio XII 55, E-31008 Pamplona, Spain

2. Area de Hemato-Oncología, IDISNA, CIBERONC, Center for Applied Medical Research (CIMA), University of Navarra, Avenida Pio XII 55, E-31008 Pamplona, Spain

3. WuXi Apptec (Tianjin) Company Ltd., TEDA, No. 168 Nanhai Road, 10th Avenue, 300456 Tianjin, PR China

4. Departmento de Hematología, Clínica Universidad de Navarra, University of Navarra, Avenida Pio XII 36, E-31008 Pamplona, Spain

Funder

International Myeloma Foundation

European Regional Development Fund

Ministerio de Econom?a y Competitividad

?la Caixa? Foundation

Qatar National Research Fund

Instituto de Salud Carlos III

Centro de Investigaci?n Biom?dica en Red de C?ncer

Foundation for Applied Medical Research, University of Navarra

Fundaci?n Fuentes Dutor