Discovery of a Janus Kinase Inhibitor Bearing a Highly Three-Dimensional Spiro Scaffold: JTE-052 (Delgocitinib) as a New Dermatological Agent to Treat Inflammatory Skin Disorders-Reference-Cited by-同舟云学术

Discovery of a Janus Kinase Inhibitor Bearing a Highly Three-Dimensional Spiro Scaffold: JTE-052 (Delgocitinib) as a New Dermatological Agent to Treat Inflammatory Skin Disorders

Published:2020-06-08 Issue:13 Volume:63 Page:7163-7185
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Noji Satoru¹^ORCID,Hara Yoshinori¹,Miura Tomoya¹,Yamanaka Hiroshi¹,Maeda Katsuya¹,Hori Akimi¹,Yamamoto Hiroshi¹,Obika Shingo¹,Inoue Masafumi¹,Hase Yasunori¹,Orita Takuya¹,Doi Satoki¹,Adachi Tsuyoshi¹,Tanimoto Atsuo²,Oki Chika²,Kimoto Yukari²,Ogawa Yoshihiro²,Negoro Tamotsu³,Hashimoto Hiromasa¹,Shiozaki Makoto¹^ORCID

Affiliation:

1. Chemical Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc., 1-1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan

2. Biological Pharmacological Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc., 1-1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan

3. Drug Metabolism & Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc., 1-1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c00450

Reference52 articles.

1. Immune response patterns in non-communicable inflammatory skin diseases

2. The burden of skin disease in the United States

3. The translational revolution and use of biologics in patients with inflammatory skin diseases

4. Mechanisms regulating skin immunity and inflammation

5. Atopic dermatitis

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