Bifunctional and Unusual Amino Acid β- or γ-Ester Prodrugs of Nucleoside Analogues for Improved Affinity to ATB0,+ and Enhanced Metabolic Stability: An Application to Floxuridine-Reference-Cited by-同舟云学术

Bifunctional and Unusual Amino Acid β- or γ-Ester Prodrugs of Nucleoside Analogues for Improved Affinity to ATB0,+ and Enhanced Metabolic Stability: An Application to Floxuridine

Published:2020-09-03 Issue:19 Volume:63 Page:10816-10828
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Sun Yongbing¹,Ke Yu¹,Li Chunshi²,Wang Jian²^ORCID,Tu Liangxing¹,Hu Lvjiang¹^ORCID,Jin Yi¹,Chen Hao¹,Gong Jianping¹,Yu Zhiqiang³^ORCID

Affiliation:

1. Division of Pharmaceutics, Jiangxi University of Traditional Chinese Medicine, No. 1688 Meiling Road, Nanchang 330004, China

2. Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, No. 103 Wenhua Road, Shenyang 110016, China

3. School of Pharmaceutical Sciences, Southern Medical University, No. 1023, Shatai South Road, Guangzhou 510515, China

Funder

National Natural Science Foundation of China

Natural Science Foundation of Jiangxi Province

Jiangxi University of Traditional Chinese Medicine 1050 Youth Talent Project

Key Project of Jiangxi

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c00149