Design, Synthesis, and Structure–Activity Relationships of Novel Tetrahydroisoquinolino Benzodiazepine Dimer Antitumor Agents and Their Application in Antibody

Design, Synthesis, and Structure–Activity Relationships of Novel Tetrahydroisoquinolino Benzodiazepine Dimer Antitumor Agents and Their Application in Antibody–Drug Conjugates

Published:2020-11-06 Issue:22 Volume:63 Page:13913-13950
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Chowdari Naidu S.¹^ORCID,Zhang Yong²^ORCID,McDonald Ivar³,Johnson Walter¹,Langley David R.³,Sivaprakasam Prasanna³,Mate Robert¹,Huynh Tram²,Kotapati Srikanth¹^ORCID,Deshpande Madhura¹,Pan Chin¹,Menezes Daniel¹,Wang Yichong¹,Rao Chetana¹,Sarma Ganapathy¹,Warrack Bethanne M.²,Rangan Vangipuram S.¹,Mei-Chen Sung¹,Cardarelli Pina¹,Deshpande Shrikant¹,Passmore David¹,Rampulla Richard²,Mathur Arvind²,Borzilleri Robert²,Rajpal Arvind¹,Vite Gregory²,Gangwar Sanjeev¹

Affiliation:

1. Bristol Myers Squibb Research & Early Development, 700 Bay Road, Redwood City, California 94063, United States

2. Bristol Myers Squibb Research & Early Development, P.O. Box 4000, Princeton, New Jersey 08543, United States

3. Bristol Myers Squibb Research & Early Development, 5 Research Parkway, Wallingford, Connecticut 06492, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c01385

Reference34 articles.

1. Antibody–Drug Conjugates (ADCs) for Personalized Treatment of Solid Tumors: A Review