Discovery of a Potent Dual SLK/STK10 Inhibitor Based on a Maleimide Scaffold-Reference-Cited by-同舟云学术

Discovery of a Potent Dual SLK/STK10 Inhibitor Based on a Maleimide Scaffold

Published:2021-08-31 Issue:18 Volume:64 Page:13259-13278
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Serafim Ricardo A. M.¹²^ORCID,Sorrell Fiona J.³,Berger Benedict-Tilman⁴⁵^ORCID,Collins Ross J.⁶,Vasconcelos Stanley N. S.¹²,Massirer Katlin B.¹²,Knapp Stefan⁴⁵^ORCID,Bennett James³,Fedorov Oleg³,Patel Hitesh⁶,Zuercher William J.⁷^ORCID,Elkins Jonathan M.²³^ORCID

Affiliation:

1. Center for Medicinal Chemistry (CQMED), Center for Molecular Biology and Genetic Engineering (CBMEG), University of Campinas (UNICAMP), Campinas, SP 13083-875, Brazil

2. Structural Genomics Consortium, University of Campinas (UNICAMP), Av. Dr. André Tosello, 550, Barão Geraldo, Campinas, SP 13083-886, Brazil

3. Centre for Medicines Discovery, University of Oxford, Old Road Campus Research Building, Old Road Campus, Roosevelt Drive, Oxford OX3 7DQ, U.K.

4. Structural Genomics Consortium, Johann Wolfgang Goethe University, Buchmann Institute for Molecular Life Sciences, Max-von-Laue-Str. 15, D-60438 Frankfurt am Main, DE, Germany

5. Institute for Pharmaceutical Chemistry, Johann Wolfgang Goethe University, Max-von-Laue-Str. 9, D-60438 Frankfurt am Main, DE, Germany

6. Medicines Discovery Institute, School of Biosciences, Cardiff University, Cardiff CF10 3AT, U.K.

7. Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States

Funder

Merck Sharp and Dohme

Bayer

Merck KGaA

Pfizer

Ontario Ministry of Economic Development and Innovation

Innovative Medicines Initiative

Genome Canada

Wellcome Trust

AbbVie

Funda????o de Amparo ?? Pesquisa do Estado de S??o Paulo

Boehringer Ingelheim