Optimization of Hydantoins as Potent Antimycobacterial Decaprenylphosphoryl-β-d-Ribose Oxidase (DprE1) Inhibitors-Reference-Cited by-同舟云学术

Optimization of Hydantoins as Potent Antimycobacterial Decaprenylphosphoryl-β-d-Ribose Oxidase (DprE1) Inhibitors

Published:2020-04-28 Issue:10 Volume:63 Page:5367-5386
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Balabon Olga¹²,Pitta Eleni¹²,Rogacki Maciej K.¹²,Meiler Eugenia²,Casanueva Ruth²,Guijarro Laura²,Huss Sophie²,Lopez-Roman Eva Maria²,Santos-Villarejo Ángel²,Augustyns Koen¹^ORCID,Ballell Lluis²,Aguirre David Barros²^ORCID,Bates Robert H.²,Cunningham Fraser²,Cacho Monica²^ORCID,Van der Veken Pieter¹^ORCID

Affiliation:

1. Laboratory of Medicinal Chemistry, Department of Pharmaceutical Sciences, University of Antwerp, Universitieitsplein 1, 2610 Wilrijk, Belgium

2. Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain

Funder

European Commission

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c00107

Reference30 articles.

1. World Health Organization. Global tuberculosis report 2019; World Health Organization: Geneva, 2019. Licence: CC BY-NC-SA 3.0 IGO. (accessed Nov 22, 2019)

2. Benzothiazinones Kill Mycobacterium tuberculosis by Blocking Arabinan Synthesis

3. Benzothiazinones Are Suicide Inhibitors of Mycobacterial Decaprenylphosphoryl-β-d-ribofuranose 2′-Oxidase DprE1

4. Structural basis of inhibition of Mycobacterium tuberculosis DprE1 by benzothiazinone inhibitors

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