Discovery of Benzopyridone-Based Transient Receptor Potential Vanilloid 1 Agonists and Antagonists and the Structural Elucidation of Their Activity Shift-Reference-Cited by-同舟云学术

Discovery of Benzopyridone-Based Transient Receptor Potential Vanilloid 1 Agonists and Antagonists and the Structural Elucidation of Their Activity Shift

Published:2021-01-01 Issue:1 Volume:64 Page:370-384
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Thorat Shivaji A.¹,Lee Yoonji²³,Jung Aeran¹,Ann Jihyae¹,Ahn Songyeon¹,Baek Jisoo¹,Zuo Dongxu¹,Do Nayeon¹,Jeong Jin Ju¹,Blumberg Peter M.⁴,Esch Timothy E.⁴,Turcios Noe A.⁴,Pearce Larry V.⁴,Ha Hee-Jin⁵,Yoo Young Dong⁵,Hong Sunhye²,Choi Sun²^ORCID,Lee Jeewoo¹^ORCID

Affiliation:

1. Laboratory of Medicinal Chemistry, College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea

2. Laboratory of Molecular Modeling & Drug Design, College of Pharmacy and Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Republic of Korea

3. College of Pharmacy, Chung-Ang University, Seoul 06974, Korea

4. Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892-4255, United States

5. Medifron DBT, Sandanro 349, Danwon-gu, Ansan-si, Gyeonggi-do 15426, Republic of Korea

Funder

National Research Foundation of Korea

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c00982

Reference33 articles.

1. Medicinal Chemistry, Pharmacology, and Clinical Implications of TRPV1 Receptor Antagonists

2. The capsaicin receptor: a heat-activated ion channel in the pain pathway