Three-Dimensional Proteome-Wide Scale Screening for the 5-Alpha Reductase Inhibitor Finasteride: Identification of a Novel Off-Target-Reference-Cited by-同舟云学术

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Three-Dimensional Proteome-Wide Scale Screening for the 5-Alpha Reductase Inhibitor Finasteride: Identification of a Novel Off-Target

Published:2021-04-12 Issue:8 Volume:64 Page:4553-4566
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Giatti Silvia¹,Di Domizio Alessandro¹²^ORCID,Diviccaro Silvia¹,Falvo Eva¹,Caruso Donatella¹,Contini Alessandro³^ORCID,Melcangi Roberto Cosimo¹^ORCID

Affiliation:

1. Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, via Balzaretti 9, 20133 Milano, Italy

2. SPILLOproject, via Stradivari 17, Paderno Dugnano, 20037 Milano, Italy

3. Dipartimento Di Scienze Farmaceutiche, Università degli Studi di Milano, 20133 Milano, Italy

Funder

Università degli Studi di Milano

Ministero dell’Istruzione, dell’Università e della Ricerca

Post-Finasteride Syndrome Foundation

European Social Fund

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c02039

Reference97 articles.

1. Kane, S. P. ClinCalc DrugStats Database, Version 20.1. ClinCalc. https://clincalc.com/DrugStats. Updated June 29, 2020 (accessed Oct 2, 2020).

2. Androgenetic alopecia; drug safety and therapeutic strategies

3. A 5-year retrospective analysis of 5α-reductase inhibitors in men with benign prostatic hyperplasia: finasteride has comparable urinary symptom efficacy and prostate volume reduction, but less sexual side effects and breast complications than dutasteride

4. Evaluation of long‐term efficacy of finasteride in Korean men with androgenetic alopecia using the basic and specific classification system

5. Safety concerns when using novel medications to treat alopecia

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2. In silico discovery of potential PPI inhibitors for anti-lung cancer activity by targeting the CCND1-CDK4 complex via the P21 inhibition mechanism;Frontiers in Chemistry;2024-06-18

3. Analysis of the finasteride treatment and its withdrawal in the rat hypothalamus and hippocampus at whole-transcriptome level;Journal of Endocrinological Investigation;2024-03-17

4. Fraisinib: a calixpyrrole derivative reducing A549 cell-derived NSCLC tumor in vivo acts as a ligand of the glycine-tRNA synthase, a new molecular target in oncology;Frontiers in Pharmacology;2024-01-03

5. Post-Finasteride Syndrome And Post-Ssri Sexual Dysfunction: Two Clinical Conditions Apparently Distant, But Very Close;Frontiers in Neuroendocrinology;2024-01

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