Structure–Activity Relationship Study Enables the Discovery of a Novel Berberine Analogue as the RXRα Activator to Inhibit Colon Cancer

Author:

Xu Beibei1,Jiang Xunjin2,Xiong Jing1,Lan Jun3,Tian Yuan1,Zhong Linhai1,Wang Xinquan3,Xu Ning3,Cao Hanwei1,Zhang Wenqing1,Zhang Hao4,Hong Xiaoting1,Zhan Yan-yan1,Zhang Yandong2ORCID,Hu Tianhui1

Affiliation:

1. Cancer Research Center, School of Medicine, Xiamen University, Xiamen 361005, China

2. Department of Chemistry and Key Laboratory of Chemical Biology of Fujian Province, iChEM, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian 361005, China

3. Department of Biological Sciences, Tsinghua University, Beijing 100084, China

4. Institute of Precision Cancer Medicine and Pathology, Jinan University Medical College, Guangzhou 510632, China

Funder

Natural Science Foundation of Fujian Province

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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