A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P-Loop Conformation-Reference-Cited by-同舟云学术

A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P-Loop Conformation

Published:2020-11-20 Issue:23 Volume:63 Page:14626-14646
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Picado Alfredo¹,Chaikuad Apirat²³^ORCID,Wells Carrow I.¹^ORCID,Shrestha Safal⁴,Zuercher William J.¹^ORCID,Pickett Julie E.¹^ORCID,Kwarcinski Frank E.⁵,Sinha Parvathi⁵,de Silva Chandi S.⁵,Zutshi Reena⁵,Liu Shubin⁶^ORCID,Kannan Natarajan⁴⁷,Knapp Stefan²³⁸⁹^ORCID,Drewry David H.¹^ORCID,Willson Timothy M.¹^ORCID

Affiliation:

1. Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7264, United States

2. Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Straße 9, Frankfurt 60438, Germany

3. Structural Genomics Consortium, Buchmann Institute for Molecular Life Sciences (BMLS), Max-von-Laue-Straße 15, Frankfurt 60438, Germany

4. Institute of Bioinformatics, University of Georgia, Athens, Georgia 30602, United States

5. Luceome Biotechnologies, 1665 E. 18th Street, Suite 106, Tucson, Arizona 85719, United States

6. Research Computing Center, University of North Carolina, Chapel Hill, North Carolina 27599-3420, United States

7. Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia 30602, United States

8. German Translational Cancer Network (DKTK) site Frankfurt/Mainz, Frankfurt am Main 60596, Germany

9. Frankfurt Cancer Institute (FCI), Paul-Ehrlich-Straße 42-44, Frankfurt am Main 60596, Germany

Funder

Deutschen Konsortium f?r Translationale Krebsforschung

Center for Scientific Review

Frankfurt cancer center

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c01174

Reference64 articles.

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5. Drak2 Regulates the Survival of Activated T Cells and Is Required for Organ-Specific Autoimmune Disease

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