Long-Acting Tumor-Activated Prodrug of a TGFβR Inhibitor-Reference-Cited by-同舟云学术

Long-Acting Tumor-Activated Prodrug of a TGFβR Inhibitor

Published:2021-10-27 Issue:21 Volume:64 Page:15787-15798
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Zhang Yong¹^ORCID,Parrish Karen E.¹,Tortolani David R.¹,Poss Michael A.¹,Huang Audris¹,Wan Honghe¹,Purandare Ashok V.¹,Donnell Andrew F.¹^ORCID,Kempson James¹^ORCID,Hou Xiaoping¹^ORCID,Pawluczyk Joseph¹,Yip Shiuhang¹,Luk Emily¹,Raghavan Nimmi¹,Swanson Jesse¹,Smalley James¹,Murtaza Anwar¹,Yang Zheng¹,Augustine-Rauch Karen¹,Lombardo Louis J.¹^ORCID,Borzilleri Robert¹

Affiliation:

1. Bristol Myers Squibb, Research and Early Development, P.O. Box 4000, Princeton, New Jersey 08544, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c02043

Reference34 articles.

1. Targeting the TGFβ signalling pathway in disease

2. The roles of TGFβ in the tumour microenvironment

3. TGF-β Inhibition and Immunotherapy: Checkmate

4. TGF-β and immune cells: an important regulatory axis in the tumor microenvironment and progression

5. TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

Cited by 4 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Supramolecular prodrug of SN38 based on endogenous albumin and SN38 prodrug modified with semaglutide side chain to improve the tumor distribution;Bioorganic & Medicinal Chemistry;2024-05

2. Advances and Challenges in Targeting TGF-β Isoforms for Therapeutic Intervention of Cancer: A Mechanism-Based Perspective;Pharmaceuticals;2024-04-20

3. Prodrugs as empowering tools in drug discovery and development: recent strategic applications of drug delivery solutions to mitigate challenges associated with lead compounds and drug candidates;Chemical Society Reviews;2024

4. Anticancer Effect of Chlorambucil Enhanced by Chiral Phthalidyl Promoiety;Chemistry & Biodiversity;2022-12-08